Genomics

Genomic testing is a management tool which enhances an animal’s pedigree by using ancestry to determine the distribution of traits. The new reference map from ARS-UCD improves genotype imputation, sequence alignment, and genomic prediction.

The Brown Swiss Association encourages breeders to test the top 25 percent of their two-year-old cows based on herdmate deviations to help identify future genetic improvers of the breed.

*Reminder - samples need to be sent to the lab prior to the 5th of the current month to receive a genomic evaluation the next month. Parentage problems may delay a genomic evaluation.

MALES NOW ELIGIBLE TO RECEIVE FULL GENOMIC EVALUATIONS
A male registration is $50, which includes a required a genomics parentage test. Breeders may also request genomic results in addition to the parentage test for an additional fee (based on Council of Dairy Cattle Breeding Fees + cost of SNP). To request a male genomic evaluation (full genomic results) after the initial parentage test, please contact Allicia at ahorn@brownswissusa.com.

NEW GENOMIC FEES

Igenity Testing Kit Costs

Blood Cards (Min. 10)	$0.50 each	$5.00 (10 cards)
Hair Cards (Min. 10)	$1.00 each	$10.00 (10 cards)
Tissue Sample Units (TSU) (Min. 10)	$2.10 each	$21.00 (10 TSU)
Applicator for TSU	$45.00 each

To order testing supplies, go to order.igenity.com or call 877-443-6489.

Igenity Pricing

Igenity Select (CDCB Parentage) - LD (9K)	$40.00 Non-Discount	$37.00 Discount
Igenity Prime (Genomics) – 50K	$46.00 Non-Discount	$42.00 Discount
Igenity Elite (AI Genomics) – 150K	$96.00 Non-Discount	$92.00 Discount

**Discount prices are for Tissue and Blood Samples; Non-Discount prices are for Hair Samples only.**

Breeders will be assessed CDCB fees according to the quality of records the herd provides, with BSA/PTPR members receiving the biggest discount. When calling or emailing Igenity to request a genomic test, the breeder’s herdcode and whether or not he/she classifies will need to be provided.

Elite, Prime, and Select testing include haplotype results for BH1, BH2, SMA, SDM, Weaver, and Polled.

Additional Tests Available (added cost)

A2 Beta Casein (add-on test)	Elite, Prime	$12.00
Y-chromosome (add-on test) (admixture=possible freemartin)	Elite, Prime, Select	$5.00
Dairy Breeding Stock Traits	-	$40.00
Dairy Recessive Traits	-	$40.00
Dairy Milk Proteins		$15.00

Red highlighted testing options are stand-alone tests that do not require other testing.

CDCB Rate Code Service Fees for Genomic Evaluations (Required)

*All animals receiving a genomic evaluation will be subject to the following fees.
Fees listed below for males are in addition to the $50 registration cost, which includes the cost of parentage.

CDCB genomic fees are structured so that those who are providing the most data of the greatest value to the cooperator database are rewarded for their contribution.

Rate Code 1   Total Program - BSA/PTPR (Production & Classification Records)
Rate Code 2    Member - CLASSIFICATION or DHIA ONLY (Production or Classification Records)
Rate Code 3     Non-Member - NO BSA/PTPR or CLASSIFICATION (No records)

Rate Code	Kind of Participation	Female Fee	Male Initial Fee	Male A.I. Service Fee
1	Total Program	$0.00	$15.00	$575.00
2	Member	$1.00	$22.00	$575.00
3	Non-Member	$3.00	$150.00	$575.00

Genomic Evaluations

Genomic Evaluations occur monthly and include results from samples sent to the lab prior to the 5th of the previous month.

Protocol for Genomic Testing Animals: Igenity Dairy Heifer Form

Contact Igenity to ask for Genetic Testing Request or e-mail dairygenomics@neogen.com with submission form.
Provide animal’s registration number, method of payment and your name and email address. (Results will be e-mailed or mailed to you.)
Send a sample to: GeneSeek Inc. - ATTN: Samples, 4131 North 48th St., Lincoln, NE 68504.
Please do NOT send samples to the Brown Swiss office.

TO REQUEST A GENOMICS EVALUATION ON AN ANIMAL THAT HAS ALREADY BEEN PARENTAGE VERIFIED:

E-mail Igenity at dairygenomics@neogen.com with your request. All parentage verification is now being done through genomics. In certain cases, for donor dams or sires for export, DNA testing may still be requested.

Genetics Docs

CDCB Genetic Evaluations

BH2 - Haplotype Affecting Stillbirth

BH1 - Haplotype Discontinued

Brown Swiss Assoc. to offer Neogen genomic services

LINCOLN, Neb., Feb. 21, 2018 — Neogen Corporation announced today that it is partnering with the Brown Swiss Association to offer its members advanced genomic services to improve herd performance and profitability.

With the agreement, Neogen will offer association members its Igenity®Dairy Heifer Program and SeekSire™ parentage product lines. Neogen’s Igenity products include its popular Igenity Select and Igenity Prime genomic profiles, which help dairy producers with selection decisions worldwide. The product line is supported by a responsive field team and innovative tools such as the Igenity Dashboard, which simplifies the process of genomic-based decision making for producers.

“We are very pleased to announce this agreement with the Brown Swiss Association, which will help its members profit from the proven benefits of genomic testing,” said Neogen’s Laurel Mastro. “What members will learn from increased genomic testing will help the Brown Swiss breed and its breeders.”

Neogen’s Igenity Dairy Heifer Program is a comprehensive program designed for dairy producers to make confident, rapid decisions on-farm utilizing genomic results. The program features three profiles for Brown Swiss cattle:
• Igenity Select, a streamlined and cost-effective profile for commercial dairy producers, which features a 17-day turnaround time guarantee
• Igenity Prime, the ideal choice for producers of breeding stock animals who would like access to add-on content
• Igenity Elite, for genomic testing of elite purebred animals

Igenity Dashboard (www.igenitydashboard.com) is an online application that allows for simple viewing and interpretation of genomic testing results. SeekSire Parentage is available to verify pedigree information on all Brown Swiss animals. Additional add-on genetic testing is also available for protein profiles and deleterious recessives known to affect Brown Swiss cattle.

To order genomic sampling kits, visit www.igenity.com. More information about Igenity can be found at www.igenitydairy.com.

Wisconsin-based Brown Swiss Association was established in 1880, registers about 10,000 animals per year, and serves about 1,800 combined adult and junior members.

Neogen Corporation (Nasdaq: NEOG) develops and markets products dedicated to food and animal safety. The company’s Food Safety Division markets dehydrated culture media, and diagnostic test kits to detect foodborne bacteria, natural toxins, food allergens, drug residues, plant diseases and sanitation concerns. Neogen’s Animal Safety Division is a leader in the development of animal genomics, along with the manufacturing and distribution of a variety of animal healthcare products, including diagnostics, veterinary instruments, wound care and disinfectants.

Weekly Preliminary Genomic Evaluations to Begin November 11, 2014

By George Wiggans, Leigh Walton, and Paul VanRaden; CDCB

Recently received genotypes will be processed each week to generate approximate genomic evaluations for new animals. Files will be posted each Tuesday morning.

The files will include preliminary genomic evaluations for new animals and for animals with genotypes that became usable since the previous weekly evaluation (for example, because of corrected pedigrees). For the convenience of recipients, the CSV files will contain the same columns as the monthly files, but data for reliability and some other columns will be left blank. Processing time will be minimized by not calculating reliability and using an approximation in the step where genomic values are combined with traditional parent average or PTA. This difference along with month-to-month changes in imputation, pedigree, and estimates of effects for single nucleotide polymorphisms (SNPs) will result in some differences between the preliminary and following month’s genomic evaluations, but correlations are very high. The immediacy of the preliminary evaluations provides an incentive to smooth the workload by submitting genotypes throughout the month rather than submitting most at the monthly due date. Another major benefit is to allow earlier sale or culling of animals (or embryos) not needed for breeding purposes to minimize the expense of raising newborn calves.